研究人員＞余冠儀 (Guann-Yi Yu)
連絡電話：(+886) 037-246166 ext.35530
|2001/08 – 2005/12
||M.S.&Ph.D., Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, U.S.
|1997/08 – 1999/05
||M.S., Molecular Microbiology, National Taiwan University, Taipei, Taiwan
|1993/08 – 1997/05
||B.S., Biology, National Cheng Kung University, Tainan, Taiwan
|2010/11 – present
||Assistant Investigator, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan
|2006/02 – 2010/10
||Postdoctoral Research Fellow, Pharmacology, University of California, San Diego, CA, U.S.
|2000/06 – 2001/07
||Research Assistant, Institute of Biochemical Sciences, National Taiwan University,, Taipei, Taiwan
|1999/05 – 2000/05
||Research Assistant, Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan
Honors & Awards
|2007 – 2010
||Mentor-based Postdoctoral Fellowship, American Diabetes Association, U.S.
The laboratory was established in November, 2010. The main theme in our research is to understand how pathogens activate innate immunity and cause tissue damage and diseases. Currently, Hepatitis C Virus (HCV) and Influenza A Virus are two main pathogens used as our research model. We aim to study how RLR (RIG-I like receptor), TLR (Toll-like receptor) and NLR (Nod-like receptor) are involved in virus (and other pathogens)-dependent cytokine and chemokine production and pathogenesis. Type I Interferon and IL-6 are two important cytokines induced during virus infection, so we are currently trying to understand how these two cytokines are regulated and their role during virus infection in vivo. Moreover, HCV infection is linked to liver cancer formation in patients, so the role innate immunity and IL-6 signaling in HCV-associated liver cancer is another important research topic in our laboratory. Molecular techniques, recombinant viruses, cell culture and genetically modified mice are the tools used in our research. Our group is open for your join and any potential collaboration.
Research Activities & Accomplishment
Main Projects, Founding agency and Lab members involved:
1. Hepatitis C Virus replication and pathogenesis in mouse model; NHRI (PP 2011-present); Chia-Yang Li, Ming-Sian Wu, Chih-Wen Hsu, Wan-Ting Tsai, Yu Tsai.
2. The role of host and virus factors in the pathogenesis of influenza A; NHRI (SP 2011-2012); Yu Tsai, Kai-Chieh Chen, Chih-Wen Hsu, Ming-Sian Wu.
3. The role of STAT3 in Hepatitis C Virus replication and liver cancer promotion; National Science Council, Taiwan (2011-2014); Chia-Yang Li, Ming-Sian Wu, Chih-Wen Hsu, Wan-Ting Tsai, Yu Tsai.
NHRI Repository: http://http://ir.nhri.org.tw/handle/3990099045/5822