研究人員>許素菁 (Shu-Ching Hsu)

 

感染症與疫苗研究所

連絡電話:(+886) 037-246166 ext.37707

傳真電話:(+886) 037-583009

電子郵箱:mschsu@nhri.org.tw  

學歷

1995/09 – 2000/01 Ph. D., Microbiology, National Taiwan University, Taipei, Taiwan
1993/09 – 1995/06 M.S., Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan
1989/09 – 1993/06 B.S., Microbiology, Soochow University, Taipei, Taiwan

經歷

2013/10 – present Join-associate Investigator, Tissue engineer and regeneration medicine, National Chung Hsing University, Taichung, Taiwan
2013/10 – present Associate Investigator, National Institute of Infectious Diseases and Vaccinology, NHRI, Miaoli County, Taiwan
2013/10 – present Join-associate professor, Graduate Institute of Life Science, National Defense University, Taipei, Taiwan
2009/07 – 2013/09 Join-assistant professor, Tissue engineer and regeneration medicine, National Chung Hsing University, Taichung, Taiwan
2006 – present Member, -, Taiwan Society for Stem Cell Research (TSSCR), –
2005/09 – 2013/09 Join-assistant professor, Graduate Institute of Life Science, National Defense University, Taipei, Taiwan
2005/09 – 2013/09 Assistant Investigator, Vaccine Research and Development Center, NHRI, Miaoli County, Taiwan
2005/07 – 2005/07 Trainer of the annual short course, medical and experimental mammalian genetics, The Jackson Laboratory, –
2003 – present Member, -, The International Society for Stem Cell Research, –
2002/05 – 2005/07 Postdoctoral Research Fellow, Center for Gene Therapy, Tulane University, Louisiana, U.S.A
2000/01 – 2002/04 Postdoctoral Research Fellow, Institute of Molecule Biology, Academia Sinica, Taiwan

Honors & Awards

2001 – 2001 Scholarship winner of Postdoctoral training of Ministry of Education, Taiwan
2000 – 2000 Award of excellent Ph. D. thesis sponsored by Dr. Chien-Tien Hsu
1999 – 1999 Award of excellent Ph. D. student sponsored by Dr. Fong-Wen Shen
1998 – 1998 Award of excellent Ph. D. student sponsored by Dr. Fong-Wen Shen
1995 – 1995 Award of excellent master thesis sponsored in IMB, Academia Sinica
1993 – 1993 Winner of scholarship of The Phi Tau Phi Scholastic Honor Society
   

Research Interests

Dr. Hsu obtained her Ph.D. in the department of microbiology at College of Medicine, National Taiwan University, Taiwan in 2000. Dr. Hsu is very well trained in molecular immunology field at Academia Sinica, Taiwan in Dr. Ming-Zong Lai’s lab and stem cell biology at Gene Therapy Center, Tulane University, U.S.A under Dr. Darwin J Prockop’s supervised. Dr. Hsu joined the Vaccine Center, National Healthy Research Institutes, Taiwan, in 2005. Current research projects of Dr. Hsu are dividing into two parts: one is the establishment of animal models for studying human infectious diseases, and the other one is the identification and characterization of immune-modulatory activity of mesenchymal stem cells (MSCs), particular focus on how MSCs alter the outcome of differentiation and effective function in different subsets of immune cell and what application of immuno-suppression of MSCs for vaccination and immunotherapy. Her lab has developed human CB-CD34+ HSCs reconstituted NOD/SCID and NOG mice which can present human -CD19, -CD14, -CD3 positive cells and human specific IgM and IgG immune-globulins. The humanized platform will provide suitable experimental animal models for DV and TB projects in NIIDV, NHRI. Furthermore, her lab recently has provided novel insights to clarify the role of T lymphocyte and MSC interactions in developing the innate immune system after HSC reconstitution. This work may facilitate the development of a potential therapeutic approach for future clinical HSC transplantations that affects neutrophil generation.   In addition, Dr. Hsu’s lab has also set up the platforms for in vitro differentiation of different subsets of human lymphocytes and human DCs that could be served as useful models for studying and evaluating the manipulation of humeral immunity in either preventive or therapeutic vaccinology. Several MSCs derived factors which can regulate the differentiation of T lymphocytes and myeloid-derived suppressor cells (MDSCs) have been identified by Dr. Hsu’s group. She has demonstrated that GRO chemokines that were secreted from MSCs inhibited the differentiation and function of MDDCs, and drove their differentiation toward an MDSC-like immunophenotype both in vitro and in vivo. The results from this study offer novel insights into the potential therapeutic platform that is effective to generate MDSCs capable of suppressing uncontrolled immune activation. Beside research in the vaccine development, she is in charge to response the manipulation/regulation of the X-ray irradiator in NHRI, the training course for all users to operate that irradiator in a safety manner are under her supervises. Dr. Hsu spent her teaching effort in either stem cell biology or immunology course at National Chung HsingUniversity and National Defense University.

Research Activities & Accomplishment

Dr. Hsu has authored 23 original research articles, 4 book/chapters and 12 abstracts for international scientific research meetings, she also has been an invited speaker in 5 international symposia on the stem cells field. Dr. Hsu has established the MKK3/6 DN transgenic system for studying the roles of p38 signaling pathway during the development and activation of T lymphocytes. She was recognized by research contribution of knowing the regulation of Fas and FasL within T cell activation. Recently, characterization of MSCs of her work was indicated the importance of cell status and specific expression molecules on stem cells could determine the out come of tissue distribution after cellular transplantation. The roles of genetic and epigenetic controlling machinery of MSC in developmental biology and immunology will be the focus of future investigation. Furthermore, Dr. Hsu will continue to make efforts in establishment of humanized mice model system and provides the various screening platforms both in vitro and in vivo to support vaccine projects within NIIDV.

 

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